Halfway by his profession, Cees Dekker reinvented himself. Right after years of hardcore physics, he shifted his concentrate to ‘nanobiology’ with the transform of the millennium. A time period he coined himself, as a matter of point.
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Dynamics of initiation, termination and reinitiation of DNA translocation because of the motor protein EcoR124I
Non-equilibrium folding of particular person DNA molecules recaptured as many as a thousand periods in a very stable point out nanopore
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Microbiology has only been around for any century, due to the fact we began to analyze micro-organisms extra seriously. I thought nanobiology was an appropriate term, simply because all molecular biological related interactions take place in the nanoscale: a protein is several nanometres in measurement, DNA is 2 nm thick.’
‘At the outset we looked at biological devices using a Actual physical view and acted on The idea with the resources we understood. It took a number of years prior to we started off working a lot more on the large Organic issues. I then started to phone it nanobiology, a time period that didn't exist at some time.
Nanopores stand for a sublime and multipurpose Software to evaluate one molecules. We investigate novel detection modes with solid-point out nanopores as well as various ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
2003, demonstrated the first biosensors made outside of a carbon nanotube; solved the framework and mechanism of DNA restore proteins; and discovery of a brand new method for fabricating solid-point out nanopores for DNA translocation
‘The fantastically subtle way in which elements in mother nature purpose never ever ceases to amaze me. If we remedy the puzzle of how lifestyle came into remaining, I be expecting that my amazement with the complexity of development can have elevated and with it my awe with the greatness with the Creator.’
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2001, discovery of solitary-electron transistors at space temperature determined by nanotubes; realization of initially logic circuits with carbon nanotube products; and discovery of your molecular composition of DNA maintenance enzymes with AFM
Developments in nanotechnology from the nineties designed making Digital products from one molecules a probability. Cees Dekker recounts how his staff produced a room-temperature transistor according to just one carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and solitary-molecule experiments